Benzenesulfonyl chloride, 2-Methoxy-4-Methyl-
2-Methoxy-4-methylbenzenesulphonyl chloride
CAS: 216394-11-5
Molecular Formula: C8H9ClO3S
Benzenesulfonyl chloride, 2-Methoxy-4-Methyl- - Names and Identifiers
Benzenesulfonyl chloride, 2-Methoxy-4-Methyl- - Physico-chemical Properties
| Molecular Formula | C8H9ClO3S |
| Molar Mass | 220.67 |
| Density | 1.326g/cm3 |
| Melting Point | 87-89°C |
| Boling Point | 319.9°C at 760 mmHg |
| Flash Point | 147.3°C |
| Vapor Presure | 0.000614mmHg at 25°C |
| BRN | 2838636 |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.529 |
Benzenesulfonyl chloride, 2-Methoxy-4-Methyl- - Risk and Safety
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3261 |
| Hazard Class | 8 |
| Packing Group | II |
Benzenesulfonyl chloride, 2-Methoxy-4-Methyl- - Introduction
chloride is an organic compound with the chemical formula C9H11ClO3S and a molecular weight of 234.70g/mol. It has the form of a light yellow liquid or solid and is soluble in organic solvents such as methylene chloride and diethyl ether.
chloride is commonly used in protecting group reactions in organic synthesis, and can be used for sulfonylation of amines, alcohols, phenols and other compounds. The sulfonyl chloride group can react with the functional group to generate the corresponding sulfonamide, sulfonyl ether or sulfonyl phenol and other substituted products. It can also be used as an intermediate or reagent in organic synthesis.
Preparation of chloride can be obtained by chlorination of 2-methoxy-4-methylbenzenesulfonic acid. Phosphorus chloride (PCl5) is usually added dropwise to The sulfonic acid under ice-water bath conditions, and hydrogen chloride gas is released during the reaction. The obtained product can be purified by crystallization to obtain pure product.
Regarding safety information, chloride is an irritant and may cause irritation and damage to the eyes, skin and respiratory system. Wear appropriate protective equipment such as goggles, gloves and protective masks during operation. Avoid direct contact with skin and inhalation of vapors. After use should pay attention to clean, and properly stored, avoid contact with flammable and oxidant. If discomfort occurs, seek medical attention immediately.
chloride is commonly used in protecting group reactions in organic synthesis, and can be used for sulfonylation of amines, alcohols, phenols and other compounds. The sulfonyl chloride group can react with the functional group to generate the corresponding sulfonamide, sulfonyl ether or sulfonyl phenol and other substituted products. It can also be used as an intermediate or reagent in organic synthesis.
Preparation of chloride can be obtained by chlorination of 2-methoxy-4-methylbenzenesulfonic acid. Phosphorus chloride (PCl5) is usually added dropwise to The sulfonic acid under ice-water bath conditions, and hydrogen chloride gas is released during the reaction. The obtained product can be purified by crystallization to obtain pure product.
Regarding safety information, chloride is an irritant and may cause irritation and damage to the eyes, skin and respiratory system. Wear appropriate protective equipment such as goggles, gloves and protective masks during operation. Avoid direct contact with skin and inhalation of vapors. After use should pay attention to clean, and properly stored, avoid contact with flammable and oxidant. If discomfort occurs, seek medical attention immediately.
Last Update：2024-04-10 22:29:15
